When Depression Accompanies Pain

When Depression Accompanies Pain

Depression is the most common mental health disorder, and the leading cause of disability in the world. One in five individuals will suffer depression in their lifetime. Psychological symptoms include depressed mood, loss of interest or pleasure, feelings of worthlessness…

#16 Antidepressants and Neuropathic Pain

#16  Antidepressants and Neuropathic Pain

Antidepressants such as amitriptyline, nortriptyline, and despiramine are first-line treatments for neuropathic pain. They are known as tricyclic antidepressants. But how do these drugs, used to enhance mood, also reduce pain? There is a major overlap in the neural mechanisms that…