#16 Antidepressants and Neuropathic Pain

#16  Antidepressants and Neuropathic Pain

Antidepressants such as amitriptyline, nortriptyline, and despiramine are first-line treatments for neuropathic pain. They are known as tricyclic antidepressants. But how do these drugs, used to enhance mood, also reduce pain? There is a major overlap in the neural mechanisms that…