PO Box 72068 RPO Glenmore Landing Calgary, Alberta, Canada T2V 5H9

#9 How Acetyl-L-Carnitine (HCI) Creates Energy

Acetyl-L-Carnitine is a supplement used in nerve health. 
Image Source: Canva.com

What is Acetyl-L-Carnitine?

Acetyl-L-carnitine (ALC) is a nutrient and dietary supplement that is made from L-carnitine in the body. L-carnitine and acetyl-L-carnitine are used to help the body turn fat into energy. ALC is important for many body processes, including brain function, muscle movement, and heart function.

How does Acetyl-L-Carnitine benefit peripheral neuropathy?

One of the potential benefits of ALC is its ability to reduce nerve pain in people with peripheral neuropathy. Peripheral neuropathy is a condition that affects the nerves outside of the brain and spinal cord, causing pain, weakness, and numbness in the hands and feet. According to a Mayo Clinic article, acetyl-L-carnitine is a naturally occurring amino acid that helps to reduce oxidative stress and is believed to be involved in nerve cell function and regeneration. It has been shown to have therapeutic benefits for neuropathy, including pain reduction, promoting peripheral nerve regeneration, and a neuroprotective effect. In clinical trials, people who had diabetic neuropathy had reduced pain, improvements in other sensory problems, and improvements in nerve function tests.

Is there credible evidence?

A systematic review and meta-analysis of randomized controlled trials found that acetyl-L-carnitine significantly reduced visual analogue scale (VAS) scores of peripheral neuropathic pain (PNP) patients compared with placebo. The effect of ALC on VAS was similar in different administration routes (intramuscular-oral sequential subgroup and oral only subgroup), and ALC appeared more effective in diabetic PNP patients than non-diabetic PNP patients. No severe adverse events were reported related to ALC.

Overall, the current evidence suggests that ALC has a moderate effect in reducing pain measured on VAS in PNP patients with acceptable safety. A typical dosage of ALC for people with neuropathy is 500 milligrams twice per day. However, it is always important to consult with a healthcare professional before starting any new supplement regimen.


ALC is a nutrient and dietary supplement that has many potential benefits for both mental and physical health. While more research is needed to fully understand the effects of ALC supplementation on peripheral neuropathy, current evidence suggests that it may have potential as a treatment for reducing nerve pain.

Other CNA Resources:

We can't do it alone.

Food for thought...


  1. Mayo Clinic Staff. (2019). Acetyl-L-Carnitine: Uses, Side Effects, Interactions, Dosage, and Warning. Mayo Clinic.
  2. Healthline Editorial Team. (2019). Acetyl-L-Carnitine: Benefits, Side Effects, Dosage, Interactions. Healthline.
  3. Li S., Li Q., Li Y., Li L., Tian H., & Sun X. (2015). Acetyl-L-Carnitine in the Treatment of Peripheral Neuropathic Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS One.
Share this article

Subscribe to our newsletter

Skip to content